Osawa Takao as Minakata Jin
A brain surgeon who went back in time to Edo in the era of the Tokugawa shogunate as a result of an accident. Although he constantly battles an inner conflict that saving the people of Edo may change the course of history, he continues to treat a stream of patients and the wounded against all odds because it is his mission as a doctor. He earned the respect of the people around him for the dramatic progress that medical technology made in the Edo period such as the purification of natural penicillin, but on the other hand, there are also people jealous of him and his achievements. Before long, he has to confront the assassination of his friend, Sakamoto Ryoma, with whom he has forged a deep relationship of trust. However … … ?!
Nakatani Miki as Tomonaga Miki / Nokaze
Tomonaga Miki: Jin’s one-time fiancee who looks exactly like Nokaze. She had been a brilliant pediatrician. However, she was diagnosed with a brain tumour and asked Jin to perform a surgery on her. But it failed and she is now in a vegetative state.
Nokaze: A former Yoshiwara courtesan of the highest rank. However, just as her redemption was decided, she discovered that she had breast cancer. She wanted Jin, whom she loved, to operate on her, and her life was saved. She has now set up a calligraphy school in Yokohama, but … …
Ayase Haruka as Tachibana Saki
The eldest daughter of the Tachibana family. Although the daughter of a samurai, she was entranced by the miraculous medical techniques that saved the life of her older brother, Kyotaro, and eventually assists as a nurse under Jin. Day by day her feelings for Jin grew, and she was not able to give up the path of medicine despite being a girl. Her arranged marriage to a retainer of the shogun was broken off on the day of the presentation of betrothal gifts and she was disowned by her mother, Ei. She now lives at Jinyudo and supports the doctors while doing all the domestic chores.
Koide Keisuke as Tachibana Kyotaro
A young samurai whose life was saved by Jin. The eldest son of the Tachibana family and Saki’s older brother. He has a serious personality, and wishes from the bottom of his heart to “do what a samurai must do” and “protect the shogunate”, as he places himself in the shogunate’s cossetted world of retainers. He looks up to Katsu Kaishu as his mentor and respects him.
Aso Yumi as Tachibana Ei
The mother of Saki and Kyotaro. A strict woman who values the pride of a samurai family. Her husband died in a cholera outbreak. After Saki’s arranged marriage is broken off, she falls sick … …
Kohinata Fumiyo as Katsu Kaishu
The mentor of Sakamoto Ryoma and Tachibana Kyotaro. He has a broad international perspective and advocates policies for Japan to hold its own against other countries. He meets Jin through Kyotaro and takes a strong interest in Jin’s medical techniques. His younger sister is married to Sakuma Shozan who is older than him, but Sakuma acts as his “younger brother-in-law”.
Uchino Masaaki as Sakamoto Ryoma
A Tosa-born wandering samurai without a master to serve. A vibrant captivating personality who loves women. He is initially has doubts about Jin’s true character, but he identifies with his passionate devotion of using medical techniques to fight, and they are now best friends. Just like in historical facts, he takes interest in foreign trade and secretly swings into action to overthrow the Tokugawa shogunate.
Ichimura Masachika as Sakuma Shozan
Katsu Kaishu’s “younger brother-in-law” and a feudal retainer well-versed in artillery and military strategy. Called a “gifted thinker once every 100 years”, he was also famous as the greatest scholar of Western knowledge. However, he was attacked by someone for loudly advocating the progressive opening of the country to the world, and sustained critical injuries.
Fujimoto Takahiro as Saigo Takamori
Born as the child of a low-class samurai of the Satsuma domain, he experienced hardship and many setbacks in his adolescence. He made his make in policy proposal and developed that talent. He was suddenly overcome by a mysterious abdominal pain while leading the Hamaguri Rebellion, and is examined by Jin, but … …
Sato Ryuta as Higashi Shusuke
A Choshu-born samurai. He was also attacked by the Shinsengumi in the Hamaguri Rebellion and rescued by Sakamoto Ryoma. He survives because of Jin’s surgery. This makes him become Ryoma’s bodyguard.
Ichikawa Kamejiro as Nakaoka Shintaro
A patriot who belong to the faction advocating the expulsion of foreigners. Like Sakamoto Ryoma, he hailed from Tosa domain. A sworn ally whom Ryoma described as “a person like me”, he formed the Rikutentai when Ryoma established the Kaientai. He ran about with Ryoma to orchestrate the reconciliation of the Satsuma and Choshu domains.
Kiritani Kenta as Saburi Yusuke
A young doctor who hails from Gosuido of the Hanaoka school in Osaka which made general anesthesia possible for the first time in the world. After coming up to Edo, he studied under the late Ogata Koan, but he encountered Jin, who had learnt revolutionary and remarkable medical techniques, and aspired to even greater heights. He shares Jin’s lofty aims and works as his right-hand man to continue to save the town people.
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